Contact
How to shop
Delivery
Shopping guide
Anaphase promoting complex: structure and expression
English
140 b
Up to 30 days for returns
Customers also purchased
/
Paperback
35.78
€
/
Paperback
5.77
€
/
Paperback
34.97
€
The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role in cell cycle control and known as target of anti-cancer agents. APC regulates the onset of chromosome separation and mitotic exit via securin and cyclin B degradation, respectively. APC controls this process by mediating ubiquitin conjugation to substrates such as cyclin B and securin. The objective of this study was to evaluate the expression pattern of APC subunits in cancer cell lines and AML patients. Moreover, inhibitory compounds were designed based on the 3D structure of the APC and their inhibitory effects were investigated on HeLa and MDA-MB-435 cell lines. To do this, the 3D structure of APC was predicted using homology modelling and molecular dynamic simulation. Interaction among APC subunits were studied by using protein-protein docking methods. It was found that catalytic subunits of APC over-expressed in cancer cell lines and AML patients. Furthermore, the APC subunits assembly and activation was demonstrated at the atomic-level.
About the book
English
Categories
Give this book today
It's easy
1 Add to cart and choose Deliver as present at the checkout 2 We'll send you a voucher 3 The book will arrive at the recipient's addressYou might also be interested in
/
Paperback
12.06
€
/
Hardback
39.43
€
/
Paperback
58.90
€
/
Sheet music
9.93
€
