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ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION

Name: ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION
Brand: LAP LAMBERT Academic Publishing
SKU: 42835871
Price: 38.85 EUR
Availability: InStock
Author: Prafulla Kumar Sahu
ISBN: 9786205528082

Prafulla Kumar Sahu

Language

English

Book Paperback

Libristo code: 42835871

Publishers LAP LAMBERT Academic Publishing, December 2022

Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-em... Full description

Libristo code: 42835871

95 b

38.85 €

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Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).