Chromatographic and Membrane Processes in Biotechnology

1. Chromatographic Processes.- Modelling Equilibrium and Kinetics in Chromatographic Processes.- Theory of Linear and Nonlinear Chromatography.- Hydrodynamics of Chromatographic Columns.- Cyclic Fixed Bed Sorption Processes for Bioseparations - Design Aspects.- Separations by Continuous Annular Chromatography.- Gradient Elution Chromatography.- Rate Processes in Supercritical Fluid Desorption and Extraction.- 2. Membrane Processes.- Fundamentals of Membrane Separation Processes.- Pressure-Driven Membrane Processes.- Ellectrically-Driven Membrane Processes.- Novel Membranes - Formation and Process Applications.- Cell Harvesting Using Cross-Flow Microfiltration.- Recovery of Intracellular Products.- Pervaporation in Biotechnology.- 3. Affinity Processes.- Affinity Chromatography: Principles and Applications.- Theory of Affinity Chromatography.- Affinity Partitioning.- Prediction of Partition Coefficients for Peptides in Aqueous Two-Phase Systems.- Membrane Affinity Filtration.- 4. Design of Separation Media.- Affinity Chromatography: Design of Biospecific Chromatographic Materials.- Membranes for Bioprocessing: Design Considerations.- 5. Scale-Up, Optimization and Process Integration.- Operating Modes, Scale-up and Optimization of Chromatographic Processes.- Scale-up and Optimization of Membrane Processes.- Simultaneous Reaction and Chromatography.- Membrane bioreactors.- Recombinant Human Tissue-Plasminogen Activator: Biochemistry, Pharmacology, and Process Development.- List of Contributors and Participants.