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DNA Replicons - Next-generation Vaccines against Allergy

Name: DNA Replicons - Next-generation Vaccines against Allergy
Brand: VDM Verlag Dr. Mueller E.K.
SKU: 06943333
Price: 61.79 EUR
Availability: InStock
Author: Maximilian Gabler
ISBN: 9783836495554

Maximilian Gabler

Language

English

Book Paperback

Libristo code: 06943333

Publishers VDM Verlag Dr. Mueller E.K., April 2008

In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respe... Full description

Libristo code: 06943333

149 b

61.79 €

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In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity for treatment of type I allergy. DNA replicons display specific danger signals and offer an excellent safety profile based on apoptotic elimination of transfected host cells thereby preventing undesirable long-term expression of the transfected gene. Using the model allergen beta-Galactosidase in a protective approach, the results showed that a replicase-based DNA vaccine can induce a comparable immune response at a more than 1000-fold lower dose than a conventional DNA vaccine. DNA replicon doses as low as 10 ng significantly prevented from IgE induction by subcutaneous protein sensitization. Furthermore, in a therapeutic approach with the same construct, DNA replicons balanced an ongoing allergic response. These data were confirmed with a DNA replicon encoding the clinically relevant timothy grass pollen allergen Phl p 5. In addition, lung pathology could be prevented by pre-vaccination with DNA replicons as measured by the magnitude of eosinophilia, goblet cell hyperplasia, IL-5 production and proliferation of endothelial cells.