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DNA Systems Under Internal and External Forcing

Name: DNA Systems Under Internal and External Forcing
Brand: Springer Nature Switzerland AG
SKU: 33256264
Price: 111.95 EUR
Availability: InStock
Author: Megan Clare Engel
ISBN: 9783030254155

Megan Clare Engel

Language

English

Book Paperback

Libristo code: 33256264

Publishers Springer Nature Switzerland AG, September 2020

The interactions of DNA with force are central to manifold fields of inquiry, including the de novo... Full description

Libristo code: 33256264

274 b

111.95 €

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The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.