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Genetic algorithm for haplotyping and block partitioning

Language EnglishEnglish
Book Paperback
Book Genetic algorithm for haplotyping and block partitioning Nadezhda Sazonova
Libristo code: 06831469
Publishers VDM Verlag, March 2010
A new algorithm for performing simultaneous haplotype resolution and block partitioning is proposed.... Full description
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A new algorithm for performing simultaneous haplotype resolution and block partitioning is proposed. The algorithm is based on genetic algorithm approach and the parsimonious principle. The multiloculs LD measure (Normalized Entropy Difference) is used as a block identification criterion. The proposed algorithm incorporates missing data is a part of the model and allows blocks of arbitrary length. In addition, the algorithm provides scores for the block boundaries which represent measures of strength of the boundaries at specific positions. The results show that the proposed genetic algorithm provides the accuracy of haplotype decomposition within the range of the same indicators shown by the other algorithms. The proposed algorithm is also used in a new population clustering algorithm, which extracts from the given genotype sample two clusters with substantially different block structures and finds haplotype resolution and block partitioning for each cluster.

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About the book

Full name Genetic algorithm for haplotyping and block partitioning
Language English
Binding Book - Paperback
Date of issue 2010
Number of pages 132
EAN 9783639237849
ISBN 3639237846
Libristo code 06831469
Publishers VDM Verlag
Weight 204
Dimensions 152 x 229 x 8
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