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Genomic Imprinting

Methods and Protocols

Language EnglishEnglish
Book Paperback
Book Genomic Imprinting Andrew Ward
Libristo code: 02717270
Publishers Humana Press Inc., October 2010
Genomic imprinting is the process by which gene activity is regulated according to parent of origin.... Full description
? points 249 b
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Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand.

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About the book

Full name Genomic Imprinting
Author Andrew Ward
Language English
Binding Book - Paperback
Date of issue 2010
Number of pages 377
EAN 9781617371646
ISBN 1617371645
Libristo code 02717270
Publishers Humana Press Inc.
Weight 664
Dimensions 152 x 21 x 25
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