Contact
How to shop
Delivery
Shopping guide
Quantifying Cell-Ecm Adhesion by Single Cell Force Spectroscopy
English
172 b
Up to 30 days for returns
Customers also purchased
/
Paperback
35.60
€
/
Paperback
16.74
€
/
Paperback
76.06
€
/
Paperback
30.66
€
/
Adobe ePub DRM
47.31
€
/
Paperback
25.01
€
/
Paperback
32.88
€
/
Paperback
35.10
€
Integrin-mediated adhesive interactions of cells with the extracellular matrix (ECM) regulate important cellular functions and play a critical role in disease. Therefore, studying the mechanisms underlying integrin-binding and regulation is of great interest. In the presented work three respective biological questions have been addressed using Atomic Force Microscopy based Single Cell Force Spectroscopy (AFM-SCFS). The work is split into six chapters. The first chapter provides an introduction into cell-ECM interactions. Thereafter different adhesion assays are compared and contrasted, and the theoretical Bell-Evans model is discussed. In chapter four, alpha2beta1-integrin mediated cell adhesion to collagen I is quantified. Thereafter the effects of the exposure of cryptic integrin binding sites within collagen I on pre-osteoblasts are analysed. At last, the role of BCR/ABL in modulating myeloid progenitor cell adhesion to stromal cells and ECM-coated substrates is studied. Taken together, the work demonstrates that AFM-SCFS is a versatile tool that permits monitoring of cell adhesion from single-molecule recognition events to the formation of more complex adhesion sites.
About the book
English
Categories
Give this book today
It's easy
1 Add to cart and choose Deliver as present at the checkout 2 We'll send you a voucher 3 The book will arrive at the recipient's addressYou might also be interested in
/
Paperback
12.80
€
/
Paperback
10.28
€
/
Paperback
62.04
€
/
Paperback
19.66
€
/
Paperback
25.01
€
Hi! I'm Libroamiko, your book advisor.
How can I help you?