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Signalisation cellulaire et transcription dans l'oncogenèse

Caractérisation fonctionnelle de FHL2, un nouveau partenaire de la beta-caténine

Language FrenchFrench
Book Paperback
Book Signalisation cellulaire et transcription dans l'oncogenèse Charlotte Labalette
Libristo code: 06993026
Publishers Presses Académiques Francophones, November 2011
Parmi les cancers les plus fréquents dans nos sociétés occidentales figure le cancer du colon. Les m... Full description
? points 192 b
79.15
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Parmi les cancers les plus fréquents dans nos sociétés occidentales figure le cancer du colon. Les mécanismes moléculaires sous-jacents sont remarquablement uniformes. En effet, plus de 90% des cas présentent des mutations dans les gčnes impliqués dans la voie de signalisation Wnt. L'accumulation nucléaire de la beta-caténine suite ŕ l'altération de la voie Wnt est observée dans de nombreux autres cancers comme les hépatocarcinomes cellulaires. Ce manuscrit présente de façon trčs générale les bases moléculaires et cellulaires de l'oncogenčse puis les mécanismes par lesquels la beta-caténine exerce ses fonctions oncogéniques ŕ travers son rôle dans la transcription. L'identification d'un nouveau partenaire de la beta-caténine, la protéine FHL2 composée exclusivement de domaines LIM, nous a permis d'approfondir notre compréhension de l'activité de la beta-caténine. Cette thčse effectuée ŕ l'institut Pasteur entre 2002 et 2006 nous a permis de caractériser les fonctions de FHL2 dans la régulation de la transcription, la prolifération, la transformation cellulaire et la tumorigenčse. Ainsi, FHL2 se révčle ętre une cible potentielle pour des thérapies anti-tumorales.

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About the book

Full name Signalisation cellulaire et transcription dans l'oncogenèse
Language French
Binding Book - Paperback
Date of issue 2012
Number of pages 280
EAN 9783838172903
Libristo code 06993026
Weight 433
Dimensions 150 x 220 x 17
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